[HTML][HTML] In search of a new pharmacological treatment for drug and alcohol addiction: N-methyl-D-aspartate (NMDA) antagonists

A Bisaga, P Popik - Drug and alcohol dependence, 2000 - Elsevier
… of N-methyl-d-aspartate (NMDA) receptor antagonists as treatments for substance abuse as
… It is hypothesized that NMDA receptors mediate the common adaptive processes that are …

Therapeutic potential of NMDA receptor antagonists in the treatment of alcohol and substance use disorders

A Bisaga, P Popik, AY Bespalov… - … on investigational drugs, 2000 - Taylor & Francis
N-methyl-D-aspartate (NMDA) receptor neurotransmission contributes to mediating the
behavioural effects of alcohol and other drugs of abuse. … search for a mechanism of dependence

[HTML][HTML] The role of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes

U Heresco-Levy, DC Javitt - European Neuropsychopharmacology, 1998 - Elsevier
… The ability of both noncompetitive and competitive NMDA antagonists to … pharmacological
management of human alcoholism has been limited, to a large extent, to the use of drugs that …

… -d-Aspartate (NMDA)-Receptor Antagonist MRZ 2/579 Suppresses Ethanol Intake in Long-Term Ethanol-Experienced Rats and Generalizes to Ethanol Cue in Drug …

SM Hölter, W Danysz, R Spanagel - Journal of Pharmacology and …, 2000 - ASPET
… /NMDA receptor system are now considered in the search for pharmacotherapeutic
agents that may be useful in the treatment of alcohol dependence (… NMDA N-methyl-d-aspartate

[HTML][HTML] NMDA receptor modulators in the treatment of drug addiction

SE Tomek, AL LaCrosse, NE Nemirovsky, MF Olive - Pharmaceuticals, 2013 - mdpi.com
drug addiction, and the N-methyl-d-aspartate (NMDA) glutamate receptor subtype serves as
a molecular target for several drugs of abuse… demonstrated that NMDA antagonists block the …

The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect

V Vengeliene, D Bachteler, W Danysz, R Spanagel - Neuropharmacology, 2005 - Elsevier
… of alcohol via its antagonism of the N-methyl-d-aspartate … , where uncompetitive antagonists
block the receptor in a use-… selective pharmacological agents: the competitive antagonist

Glutamatergic targets for new alcohol medications

A Holmes, R Spanagel, JH Krystal - Psychopharmacology, 2013 - Springer
… approach to treating alcohol use disorders, focusing on five … : the N-methyl-d-aspartate
(NMDA) receptor and specific NMDA … of NMDAR blockers on a variety of alcohol behaviors in …

Dose-related ethanol-like effects of the NMDA antagonist, ketamine, in recently detoxified alcoholics

JH Krystal, IL Petrakis, E Webb… - Archives of general …, 1998 - jamanetwork.com
… of the N -methyl-D-aspartate (NMDA) glutamate receptor … to a smaller subsample of alcoholics
with cocaine use histories, … to discriminate NMDA antagonists from other drugs to make …

N-Methyl-D-Aspartate (NMDA) receptor modulators: a patent review (2015-present)

H Ahmed, A Haider, SM Ametamey - Expert opinion on therapeutic …, 2020 - Taylor & Francis
… functional and pharmacological facets of NMDA receptors … that subtype-selective NMDA
receptor antagonists show an … the search for new disease areas with potential NMDA receptor …

NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy

JH Krystal, IL Petrakis, E Krupitsky… - Annals of the New …, 2003 - Wiley Online Library
… antagonism of the N-methyl-d-aspartate subtype of glutamate … receptor antagonists and
NMDA receptor antagonists might … (5) Might NMDA receptor antagonist drugs play a role in the …